Phage therapy returns to the US

Issue One | October 18, 2018
3 min read

Welcome to the first issue of Capsid & Tail, a mini-periodical of links, topics, and commentary that covers the ins and outs of the phage world.

This first issue covers Dr. Steffanie Strathdee’s path to treating her husband, Dr. Tom Patterson, with phages—one of the first major phage therapy successes in the US in decades. This led to the creation of the Center for Innovative Phage Applications and Therapeutics, or IPATH, the first phage therapy center in North America.

We’re still working hard to make Capsid & Tail a great resource for all things phage. We’re eager to hear about what you like to read about! Just answer this short, one-question form.

What’s New

Pherecydes published the long-awaited results of PhagoBurn, the first blinded, controlled, randomized phage trial on burn patients.

News

AmpliPhi just received positive FDA feedback for phase 2 clinical trials using their phage cocktails against Pseudomonas aeruginosa (AB-PA01) and Staphylococcus aureus (AB-SA01).

News

Steffanie Strathdee and Urmi S. Bajpai announced a new 12-month postdoc position starting July 2019. The postdoc will work on phages in Dr. Bajpai’s lab at ANDC in Delhi. Contact urmibajpai@andc.du.ac.in to apply (fellowship application deadline is November 15, 2018).

Jobs

Phage Futures (January 29-30, 2019) is a translational phage therapy conference where Steffanie Strathdee, Tom Patterson, the FDA, and others will discuss how we move phage therapy forward in the US. Registration is open to all - use code “PHDI10” for 10% off. We’ll also be there!

Phage Futures 2019

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Phage therapy returns to the US

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Phage microbiologist and co-founder of Phage Directory
Co-founder
Phage Directory, Atlanta, GA, United States

Jessica Sacher is a co-founder of Phage Directory and has a Ph.D in Microbiology and Biotechnology from the University of Alberta.

For Phage Directory, she takes care of the science, writing, communications, and business aspects.

Phage therapy has been around for almost a century, but has had its various starts and stops. The attempts to use phages to battle against bacterial infections were more or less halted when antibiotics became a thing in the 40’s.

In the last decade, antibiotics have started to lose their edge against bacteria, and more people are now suffering from antibiotic resistant infections.

One of these people was Tom Patterson, who suffered a case from antibiotic-resistant Acinetobacter baumanii, which he caught from a vacation trip to Egypt. Luckily for him, his wife is the associate dean of global health sciences, and an unstoppable force of nature, and was able to save his life by gathering a crack team of doctors and researchers in the nick of time.

Watch her describe her efforts in her TedX talk:

or listen to an interview on iTunes or Stitcher with Steffanie and Tom:

You can also read the case study the medical team published or hear what their head doctor, Robert “Chip” Schooley has to say about the case on the JAMA podcast (iTunes or Stitcher).

More recently, Steffanie and Tom announced that they’re publishing a memoir to detail their experiences. It’s available for preorder on Amazon, so please check it out.

The Perfect Predator book cover

Next issue, we’ll cover phage clinical trials—what’s been done, what was learned, and what’s in the works.

Thanks for reading!
~ Jan and Jessica

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