C&T Round Up for November 2022!

Issue 203 | December 2, 2022
6 min read
Capsid and Tail

Happy December, everyone. I hope you’ve all enjoyed your Thanksgiving! Jessica and I took a short break in New Zealand and it was sublime. This past month, we featured an article by Adam Yang that explored COVID-19 and phages. We also featured a series by Ruby Lin, thoroughly exploring what a sustainable phage therapy ecosystem could look like.

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What’s New

The FDA approved Rebyota, the first fecal microbiota product, for the prevention of recurrence of Clostridioides difficile infection (CDI) in individuals 18 years of age and older. Rebyota is administered rectally as a single dose and is prepared from stool donated by qualified individuals.

Biotech newsFecal Transplant

Innovate UK KTN has launched the Phage Innovation Network to drive innovation in the regulation and development of phage technologies for applications across multiple sectors, ensuring the UK maintains its strong stance on tackling antimicrobial resistance. If you would like to get involved please reach out to Francesca Hodges on francesca.hodges@iuk.ktn-uk.org.

AMRBiotech newsPhage therapy

In a new paper in Viruses, Fedor Zurabov (MicroMir, Russia) and colleagues report that phage cocktails were safely administered to thirty patients after COVID-19.

COVIDResearch paper

In a new paper in Viruses, Maik Wolfram-Schauerte and colleagues (Max-Planck-Institute for Terrestrial Microbiology) apply transcriptomics and proteomics to characterize the temporal patterns of transcription and protein synthesis during T4 phage infection of E. coli.

InfectionResearch paper

Panagiotis Zagaliotis (Weill Cornell Medicine New York) and colleagues published a new review in Pathogens and Immunity on the therapeutic phages for Gram-negative bacterial infections in animals and humans.

Multidrug resistanceResearch paper

Latest Jobs

biofilmsPhD project
The Infection Biology of Bacterial Viruses group at MSB Medical School Berlin is looking to fill a PhD position in the area of bacteriophage infection of biofilms.
Phage therapyPhD project
The University of Southampton and UKHSA are looking for a PhD student to work on a project investigating phage mitigation of Klebsiella pneumoniae infection.
AMRPhage therapyPost Doc
The Catalan Institute for Water Research, Spain is seeking a postdoctoral researcher to work on the reclaimONEwater project, which focuses on two main topics: (i) the fate of antibiotic resistance genes in physico-chemical treatment; (ii) the use of naturally occurring phages as viral surrogates.
PhD project
The University of Stuttgart is looking for a candidate to fill the PhD position “Cryo-Atom Probe Tomography of Bio-Materials” to perform experiments with cryo-preparation, atom probe tomography, and aberration-corrected TEM. The aim is to quench-freeze genetically modified phages embedded in aqueous solution and make them accessible to measurement with the atom probe.
Phage biologyPost Doc
The Institute of Translational Medicine for Health Care Systems (ITM) at MSB Medical School Berlin is looking to hire a postdoctoral researcher to study the biophysics of phage infection in their work group ‘Infection Biology of Bacterial Viruses’.
Phage-host interactionPhD project
The Forschungszentrum Jülich is looking for a PhD student to work on prokaryotic virus-host interaction in the group of Prof. Dr. Julia Frunzke. The focus will be on novel antiviral (antiphage) strategies of bacteria, including the role of secondary metabolites and their mode of action in phage defense.

Community Board

Anyone can post a message to the phage community — and it could be anything from collaboration requests, post-doc searches, sequencing help — just ask!

Phages for Global Health is planning to deliver hands-on phage workshops in Africa and Asia again, with a new curriculum that incorporates the best parts of the virtual teaching from the past year into an updated workshop curriculum with 2 components:

  • A series of virtual lectures through which phage experts from around the world will teach the key aspects of phage biology and discuss potential antibacterial applications of phages in crops, aquaculture, animals and people
  • An in-person training during which the participants will practice isolating phages from local environments in Africa and Asia and begin characterizing them

Their goal is to deliver two trainings in 2023: one for scientists from Southeast Asia and one for those in West Africa. In order to accomplish that, we need to raise the necessary funds. Please consider partnering with Phages for Global Health by making a tax deductible donation!

Phages for Global HealthWorkshop

The Africa Phage Forum will be hosting a webinar on December 6th, 2022 at 3:00 PM East Africa Time (EAT) or 12 PM GMT. The webinar, titled ‘Safety Evaluation of Phages Infecting Carbapenem-Resistant Klebsiella pneumoniae for Therapy in Low-Resource Settings’, will be given by Dr Noutin F. Michodigni, Ph.D. Register here.

Phage therapyWebinar

C&T Round Up for November 2022!

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Product designer and co-founder of Phage Directory
Co-founderProduct Designer
Twitter @yawnxyz
Skills

Bioinformatics, Data Science, UX Design, Full-stack Engineering

I am a co-founder of Phage Directory, and have a Master of Human-Computer Interaction degree from Carnegie Mellon University and a computer science and psychology background from UMBC.

For Phage Directory, I take care of the product design, full-stack engineering, and business / operations aspects.

As of Feb 2022, I’ve recently joined Jon Iredell’s group in Sydney, Australia to build informatics systems for Phage Australia. I’m helping get Phage Australia’s phage therapy system up and running here, working to streamline workflows for phage sourcing, biobanking and collection of phage/bacteria/patient matching and monitoring data, and integrating it all with Phage Directory’s phage exchange, phage alerts and phage atlas systems.

Here’s what we published this month!

Send us your thoughts, comments or questions (or write for us!) by email or Slack!

White Paper: Building a sustainable ecosystem for phage therapy

In Ruby’s series (and white paper) on phage sustainability, she discusses the potential of phage therapy as an alternative to traditional antibiotic treatments and the need for a sustainable ecosystem for its implementation. She outlines potential revenue streams, including phage manufacturing and production, clinical services, biobanking, and database/data management platform services, and discusses the benefits of phage therapy, such as cost savings and improved patient outcomes. The series and paper also focuses on the need for digitalization, centralised governance, standardised protocols, and good data management to ensure the success of a sustainable phage therapy ecosystem.

The secret killer behind COVID-19 and the potential remedy

by Adam Yang

In this article, Adam discusses how phage therapy could address COVID-19-related secondary bacterial infection (SBI), which is a major contributor to the high mortality rate. The article mentions a case-series study using phage therapy against SBI induced by COVID-19, current bottlenecks, and possible delivery methods to overcome these bottlenecks.

Throwback: Pharmacists and phage therapy: two pharmacy students weigh in

by Christine Thompson and Yasmine Bendimrad
September 4, 2020

In this issue, Christine and Yasmine discuss their interest in becoming infectious disease pharmacists and the concept of phage therapy. The article explains that infectious disease pharmacists are experts in determining which antimicrobial drugs and doses should be used in the treatment of patients with infections. It also discusses the need for antimicrobial stewardship programs and the potential of phage therapy as an alternative to traditional antibiotic treatments.

Capsid & Tail

Follow Capsid & Tail, the periodical that reports the latest news from the phage therapy and research community.

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In collaboration with

Mary Ann Liebert PHAGE

Supported by

Leona M. and Harry B. Helmsley Charitable Trust

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