Adaptive Phage Therapeutics was awarded an additional $8 Million from the U.S. Department of Defense (DoD) for the continued development of phage therapies for the treatment of infectious diseases. The new funding brings the total DoD contract awarded to APT to $31.2 million.
Necrotizing enterocolitis is a currently unpreventable life-threatening GI disorder of preterm infants. Fecal microbiota transplantation is promising, but risks transfer of pathogenic microbes. Anders Brunse (University of Copenhagen, Denmark) and colleagues published a new paper in The ISME Journal showing transplantation of fecal filtrate (which contains phages but not bacteria) safely protects against necrotizing enterocolitis in piglets.
Elyse Stachler (Eawag, Swiss Federal Institute of Aquatic Science and Technology) and colleagues published a new paper in Applied and Environmental Microbiology showing phage treatment before chemical disinfection can enhance removal of plastic surface-associated Pseudomonas aeruginosa.
Aisling Brady (University of Glasgow, UK) and colleagues published a new paper in Current Biology showing that the arbitrium system controls prophage induction. This mechanism was explored in Bacillus subtilis.
Shiraz Shah (Copenhagen University Hospital, Denmark) and colleagues published a new paper in bioRxiv showing hundreds of viral families in the healthy infant gut. These results were obtained from sequencing and analysing fecal viromes from a cohort of 647 infants at 1 year of age.