Lorenz Leitner (Balgrist University Hospital, Switzerland) and colleagues published a new paper in The Lancet Infectious Diseases on the results of a randomised, placebo-controlled, double-blind clinical trial to investigate intravesical phage therapy using the Eliava Institute’s Pyophage cocktail for UTIs in transurethral prostate resection patients. They showed non-inferiority and a favourable safety profile for the phage treatment compared to antibiotics, though phage was not superior to placebo bladder irrigation.
Tao Zuo (The Chinese University of Hong Kong) and collegues published a new paper in Cell Host & Microbe on the fecal DNA virome of 930 healthy adults from two regions in China spanning six ethnicities, including urban and rural residents. They found that geography had the strongest impact on gut virome variation, that ethnicity-distinct diets associated with viral species composition, that urbanization enhanced virome differences between individuals, and that the virome was more heterogeneous than the bacterial microbiome.
Jānis Rūmnieks (Latvian Biomedical Research and Study Center, Latvia) and colleagues published a new paper in Science Advances showing the 3D structure of 22 uncultured ssRNA phages.
Kaat Schroven (KU Leuven, Belgium) and colleagues published a new review in FEMS Microbiology Reviews on phages as drivers of bacterial virulence and their potential for biotechnological exploitation.
Alejandro González-Mora (Tecnologico de Monterrey, Mexico) and colleagues published a new review in Vaccines on phage-based vaccines for antigen delivery.